In a place denied access to basic forensic technology--and where people disappear into Israeli detention--the fate of thousands remains unknown. One of them is an autistic teenager. In the early morning dark, Abeer Skaik turned to her husband, Ali Al-Qatta, and said that today would be the day they would find their son. Ali nodded in silence, and she handed him the stack of flyers. Each bore a photograph of 16-year-old Hassan smiling widely, his shoulders loose, wearing a plain red T-shirt. He is looking directly at the camera, unguarded. On top of the page, in large letters, Abeer had written a single word in bold red ink: --an appeal. Abeer watched as Ali stepped into a car with a few close friends and drove away. They started the 30-kilometer trip south, from al-Tuffah, east of Gaza City, to the European Hospital in Khan Younis. They had heard that a group of people detained by Israel, including children, would be released there. The gate was already crowded. Families stood shoulder to shoulder, wrapped in blankets against the cold, clutching photographs and ID cards. Ali distributed the flyers among his friends. When the buses of released detainees arrived, he and the others moved slowly through the narrow gaps between clusters of people. Some of those who had just been released were being pulled into embraces. Ali waited at the edge of each reunion. "Have you seen my son?" he asked. One after another, people shook their heads.

Alexandre Rocha, a French father in Iceland, claims he lost parental rights after opposing his autistic son's sex reassignment, alleging courts prioritized ideology over his rights.

The best ways to maximize mobility and even prevent back pain. Walk, work and wake better with these hamstring stretches. Breakthroughs, discoveries, and DIY tips sent six days a week. We have some news you're gonna want to sit down for--but you probably shouldn't: Your hamstrings are, in all likelihood, an anatomical disaster for a number of possible reasons, not least of which being excessive time spent seated on them. "The hamstrings are three muscles located on the back of your thigh, and they're responsible for bending your knee and extending your hip," says Marissa Cummo, PT, DPT, assistant director of physical therapy at NYC Health + Hospitals Bellevue .

While the United States and Europe are moving cautiously forward with clinical trials, China is racing toward the commercialization of brain implants. China has made history by becoming the first nation to approve a commercially available brain chip to treat a disability. NEO, the implant developed by Neuracle Medical Technology, translates the thoughts of a person with paralysis into movements of an assistive robotic hand. After 18 months of testing that proved its safety, China's National Medical Products Administration authorized the implant for people aged 19 to 60 with paralysis caused by neck or spinal cord injuries that prevent them from moving their limbs. According Nature, the implant embedded in the skull is about the size of a coin.

Fueled by the manosphere, men are boosting their testosterone levels through natural and synthetic means, with some competitively swapping test results on a regular basis. Mark Holman was skinny and depressed when he was working a 9-to-5 job as an air quality engineering consultant in 2018. "I felt weak, like a boy," says the 33-year-old New Orleans native. Determined to turn things around, he spent the next few years becoming a health coach and getting chiseled abs. But in 2021, after becoming perplexed as to why he was disinterested in sex with his partner at the time, he decided to test his testosterone levels.

Abigail Marsh has found that many psychopaths don't want to be cruel and uncaring, and argues that they deserve support to help them get there Think of a psychopath and you probably picture someone dangerous, someone whose ruthless self-interest leads to great harm for others and considerable success for themselves. Perhaps unsurprisingly, while only around 1 per cent of people in the general population have psychopathy, roughly 1 in 5 men in prison show signs of it, and research has also found a link between corporate leadership and psychopathic traits . But just as it is painful to know a psychopath, it isn't necessarily fun to be one either. Abigail Marsh, a professor of psychology and neuroscience at Georgetown University in Washington DC, studies those with psychopathic traits who largely lead ordinary lives among us. She has uncovered something surprising: many don't want to be psychopathic at all. Researchers are still honing the precise definition, but psychopathy is characterised by callousness, a lack of empathy, glib social charm and impulsivity.

This paper presents a probabilistic-graphical model that can be used to infer characteristics of instantaneous brain activity by jointly analyzing spatial and temporal dependencies observed in electroencephalograms (EEG). Specifically, we describe a factor-graph-based model with customized factor-functions defined based on domain knowledge, to infer pathologic brain activity with the goal of identifying seizure-generating brain regions in epilepsy patients. We utilize an inference technique based on the graph-cut algorithm to exactly solve graph inference in polynomial time. We validate the model by using clinically collected intracranial EEG data from 29 epilepsy patients to show that the model correctly identifies seizure-generating brain regions. Our results indicate that our model outperforms two conventional approaches used for seizure-onset localization (5-7% better AUC: 0.72, 0.67, 0.65) and that the proposed inference technique provides 3-10% gain in AUC (0.72, 0.62, 0.69) compared to sampling-based alternatives.

Computational models in fields such as computational neuroscience are often evaluated via stochastic simulation or numerical approximation. Fitting these models implies a difficult optimization problem over complex, possibly noisy parameter landscapes. Bayesian optimization (BO) has been successfully applied to solving expensive black-box problems in engineering and machine learning. Here we explore whether BO can be applied as a general tool for model fitting. First, we present a novel hybrid BO algorithm, Bayesian adaptive direct search (BADS), that achieves competitive performance with an affordable computational overhead for the running time of typical models. We then perform an extensive benchmark of BADS vs. many common and state-of-the-art nonconvex, derivative-free optimizers, on a set of model-fitting problems with real data and models from six studies in behavioral, cognitive, and computational neuroscience. With default settings, BADS consistently finds comparable or better solutions than other methods, including `vanilla' BO, showing great promise for advanced BO techniques, and BADS in particular, as a general model-fitting tool.

Linear regression models have been successfully used to function estimation and model selection in high-dimensional data analysis. However, most existing methods are built on least squares with the mean square error (MSE) criterion, which are sensitive to outliers and their performance may be degraded for heavy-tailed noise. In this paper, we go beyond this criterion by investigating the regularized modal regression from a statistical learning viewpoint. A new regularized modal regression model is proposed for estimation and variable selection, which is robust to outliers, heavy-tailed noise, and skewed noise. On the theoretical side, we establish the approximation estimate for learning the conditional mode function, the sparsity analysis for variable selection, and the robustness characterization. On the application side, we applied our model to successfully improve the cognitive impairment prediction using the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort data.

Decoding sensory stimuli from neural signals can be used to reveal how we sense our physical environment, and is valuable for the design of brain-machine interfaces. However, existing linear techniques for neural decoding may not fully reveal or exploit the fidelity of the neural signal. Here we develop a new approximate Bayesian method for decoding natural images from the spiking activity of populations of retinal ganglion cells (RGCs). We sidestep known computational challenges with Bayesian inference by exploiting artificial neural networks developed for computer vision, enabling fast nonlinear decoding that incorporates natural scene statistics implicitly. We use a decoder architecture that first linearly reconstructs an image from RGC spikes, then applies a convolutional autoencoder to enhance the image. The resulting decoder, trained on natural images and simulated neural responses, significantly outperforms linear decoding, as well as simple point-wise nonlinear decoding. These results provide a tool for the assessment and optimization of retinal prosthesis technologies, and reveal that the retina may provide a more accurate representation of the visual scene than previously appreciated.